Hourou Musuko

The story depicts a young student named Shuichi Nitori, described by the author as a transgender girl, and Shuichi's friend Yoshino Takatsuki, described as a transgender boy. The series deals with issues such as being transgender, gender identity, and the beginning of puberty. *Please note that this series was 11 episodes when aired on TV but 12 episodes when it was released on BD & DVD. See "Hourou Musuko Specials."* (Source: Wikipedia)